Studies on tableting properties of lactose. VIII. The effect of variations in primary particle size, percentage of amorphous lactose and addition of a disintegrant on the disintegration of spray-dried lactose tablets

Abstract

Disintegration of tablets compacted from spray-dried lactose samples was found to depend on the amount of amorphous lactose, the size of the primary particles and the compaction load, respectively. The poor disintegration properties of amorphous lactose was explained by pointing to the dissolution characteristics of the substance. Considerable improvement of the disintegration properties can be obtained by addition of suitable disintegrants.