STUDIES ON STRONTIUM METABOLISM FOLLOWING STRONTIUM-CALCIUM DISCRIMINATION IN DOMESTIC ANIMALS : V. EFFECTS OF VARIOUS SALTS AND WHOLE-BODY COBALT-60 GAMMA IRRADIATION ON THE STRONTIUM-CALCIUM DISCRIMINATION IN THE GOAT AND FOWL

Abstract

In this article are described the studies on the excretion, absorption, and strontium-calcitv-m discrimination in the goat and fowl to which had been administered, orally, various salts following oral doses of strontium-90 arnd calcium-45, aztd also in the fowlsubjected to whole-body Co-GO gamma irradtation following oral, or intravenous doses ofthe tracers. The results obtained are sumnmarized as follows :t. Through the adrruirtistration of sodium citrate it was fountd that the increase ofstrontium excretion was greater than that of the calcium excretioru, in the fowl, but inthe goat the effect of the citrate on calcium was greater than on stronti.um.2. In the fowl, to which sodium ethylenediamine tetra-acetate (Na-EDTA) had beenadministered, orally, the effects on the metabolism of strontium were greater than thoseon the metabolism of calcium. The metabolisms of calcixum and strontium were moreaffected by the administratiorn of Na-EDTA than by the adrninis, ration of sodiu-m ci, rate.3. When sodium tartrate was orally administered soon after the oral dose of strontium-90 and calcium-45, in the fowl, the retention of strontium and calcium showed slight de-creases, but the action of tartrate was rnuch wealcer than that of citrate.4. Through the oral administration of magnesium sulfate to the goat antd fowl, whichwere dosed, orally, with strontium-90 and calcium-45, an increase in the excretion ofstrontium-90 and calcium-45, a decrease in the bone retention of them, and the sliglnt fallof 0Rsone-aose values>were observed. In reuard to the actior? of maunesiumt the effect onstrontium was rather greater than the effect on calcium. Furthermore, the action ofmagnesium seemed to be very rapid and trautsitory.5. Through the oral administration of sodium phosphate to the fowl dosed, orally, with strontium-90 and calcium-45, the excretion and absorption of both stroratium-90 andcalcium-45 were affected, but the action on calcium seemed to be greater. It appearedthat the effects of phosphate on the urinary excretion, and endogenous fecal exeretion, were greater than those of magnesium.6. When strontium-90, and calcium-45, were administered, orally, to the fowl after ithad undergone whole-body Co-GO gammna-irradiation, the decrease in the retention ofstrontium-90 was greater than in the case of caleium-45, and the bone retention factor ofstrontium was lowered, but it was rather heightened in the case of an intravenous dose ofthe tracers.Thus the administration of various salts or Co-GO gamrrua-irradiation to the fowl andgoat caused a change in the excretion and absorption of strontium and ca