Studies on Streptomyces Antibiotic, Cycloheximide. VIII. Hydroxycarbonylation of Optically Active 2, 4-Dimethylcyclohexanone and Chemical Correlation of the Products. (2)

Abstract

The chemical correlations were examined of optically active 2, 4-dimethyl-6-(α-hydroxy (ρ-substituted) benzyl) cyclohexanones whose preparations were reported in the preceding paper. From the present experiments, tohether with the previous informations, following facts were noticed. 1) All of the optically active 2, 4-dimethyl-6-(α-hydroxy (ρ-substituted) benzyl)cyclohexanones prepared by Nielsen's condensation procedure had the same configuration, whereas those by aldol condensation had not always the same one. 2) Some of Nielsen's condensation products were converted chemcially into more stable isomers of positive [α]D value and some of the converted products tallied with the product obtained by aldol condensation procedure.