Abstract
HAVING STUDIED THE EFFECTS of stilbestrol in the female rat, normal castrate and immature (1, 2) and found them to be typical of the natural estrogens we investigated its effect in male rats. This study was undertaken to see if stilbestrol produced the same histological changes as the natural estrogens in the pituitary, thyroid, adrenals, gonads and liver and to determine if it were any more toxic in the male than in the female. Corn oil solutions of both estrogens were used. The natural estrogens2 and stilbestrol3 employed were from the same lot as was used in the female rats. Stilbestrol was given at 5 different dose levels, namely, 250, 100, 50, 5 and 1γ daily. The natural estrogens were given at 4 different dose levels in the normal male rats.
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