Abstract
IN THE PREVIOUS PAPER (I) in this series we were unable to find toxic effects of stilbestrol in doses 500 times the physiologic dose. Accordingly we decided to determine the effect of much larger doses over a long period of treatment. Young immature female rats weighing 55 to 65 gm. at the start of treatment were used. In the first group designated as series A injections of 1.25 mg. of stilbestrol were given three times weekly. A second group, series B, were given 2.5 mg. of stilbestrol three times weekly. A third group, series C, served as controls. The animals were weighed at the time injections were given and at autopsy. The body length from tip of nose to tip of tail and tail length were measured at the same times. Very little difficulty was en-countered in making these measurements as the young rats quickly became condi-oned to the handling and no real restraint was necessary.
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