Abstract
SUMMARY Administration of splenic microsomal RNA extracts to pyridoxine-deficient rats had been previously shown to increase viability of subsequent skin homografts. The following observations on the specificity of action of splenic extracts have been made: (1) treatment of splenic microsomal RNA extracts with ribonuclease or alkali destroyed their ability to prolong viability of skin grafts; (2) splenic microsomal RNA extracts administered in combination with splenic extracts prepared from the mitochondrial or soluble fractions had no beneficial effect; (3) an RNA extract obtained from a rat of genetic strain other than that of the skin donor was ineffective; and (4) microsomal RNA derived from the spleen of the skin donor failed to increase viability of the skin graft when administered to a normal recipient.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
