Abstract
Summary.The problem concerning the mechanism of the development of hyperphosphatasemia in obstructive jaundice has been taken up for renewed examination on rabbits, which have been found suitable for such experiments.1. The increase in serum phosphatase after ligation of the common bile duct starts immediately and reaches a maximal value 15 to 20 times greater than the normal value in about 15 hours, followed by a slow drop during the next days.2. The increase in the serum phosphatase is a real rise in the amount of phosphatase.3. The increase in serum phosphatase is not released from the common bile duct.4. The results of the experiments do not support the “activiation theory”. Nor can they be explained by the absence of bile in the intestine.5. The retention of bile phosphatase alone cannot explain the hyperphosphatasemia.
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