Abstract
Experiments to determine the role of particle size in the infectivity of anthrax spores are described. Clouds of homogeneous particles were produced. The mortality-dosage curves for guinea-pigs and monkeys are given for clouds of various particle sizes. Data are given on the effect of time in the concentration-time relationship. The results are compared with those recorded by other workers on the relationship of particle size to respiratory retention.Infectivity was highest with single-spore clouds, falling off as particle size increased. Reasons are given for attributing this effect to difference in site of deposition of different-sized particles.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have