Abstract

IN A RECENT PUBLICATION (i) the deleterious effects of stilbestrol on the male reproductive system were discussed. Since considerable regressive changes were found in the testes, seminal vesicles and prostate it was obviously desirable to ascertain not only if these organs could recover a functional level but also to determine the length of time necessary for this recovery after the withdrawal of treatment. With these objectives in mind experiments designed to elucidate the problem were executed. Data collected from these studies are presented in this communication. Sixty-six (32, male and 34 female) young but sexually mature albino rats of Wistar stock inbred for many generations were used for the work The sodium salt of stilbestrol was made by dissolving 20 mg. of stilbestrol in 0.5 cc. of IN NaOH. The desired concentration was attained by dilution with distilled water

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