Abstract
AbstractA series of biodegradable porous hydrogels, based on thermosensitive N‐isopropylacrylamide (NIPAAm) and biodegradable crosslinker‐polycaprolactone diacrylate (PCLdA) that was synthesized from polycaprolactone diol with acryloyl chloride were prepared by photopolymerization at low temperature. The effect of the crosslinker content and gelation method on the swelling behaviors and physical properties for the poly(NIPAAm) hydrogels was investigated. Results showed that the swelling ratio of the gel in deionized water decreased with an increase of the content of polycaprolactone (PCL) segment in the poly(NIPAAm) hydrogels. The properties of the gels crosslinked with PCLdA were compared with those crosslinked with N, N′‐methylenebisacrylamide (NMBA). The results showed that the critical gel transition temperatures (CGTT) of the gels crosslinked with PCLdA were lower than those of the gels crosslinked with NMBA due to the hydrophobicity of the PCL segment. The results also showed that the gels crosslinked with PCLdA had higher mechanical strength and crosslinking density than those gels crosslinked with NMBA. Comparing the porous gels with nonporous gels, the results showed that the swelling ratio and CGTT of the porous gels were higher than those of the nonporous gels, and the transition temperature curve was smoother for the porous gels. The porous gels also exhibited more rapid thermal response and faster degradation rates. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008
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