Abstract
The mechanism of the stimulatory effect of chelating agents, such as DL-penicillamine and citric acid, on the biliary excretion of cadmium in rats was studied. The results of Sephadex G-75 gel filtration of liver soluble fraction of rats administered cadmium with or without these chelating agents indicated that the chelating agents significantly depressed the binding of cadmium to a high molecular weight protein of liver tissue. The cumulative biliary excretion of DL-penicillamine and citric acid in a 9 h period after administration were about 1% and about 0.04% of the dose, respectively. It is suggested that the stimulatory effect of DL-penicillamine on the biliary excretion of cadmium was due to the formation of DL-penicillamine-cadmium complex, and that citric acid depressed the binding of cadmium to high molecular protein in the liver cytosol, resulting in enhanced biliary excretion of cadmium.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
