Abstract
Among the various hydrolases, Pig Liver Esterase (PLE) is possibly the most widely used enzyme, particularly for the preparation ~f chiral synthons *'2 and for chemo 3 and regioselective transfo .~6ations. Various active site models for PLE have been proposed' , the cubic space model of Jones et al. s having received most attention. We report the reactivities of methyl esters containing large hydrophobic substituents toward PLE catalysed hydrolysis, and discuss the results in the light of Jones' model.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have