Abstract
Studies on Pharmacokinetics and Liver Microsome Metabolism of Nuciferine in Different Species of Animals
Highlights
According to Chinese Pharmacopoeia, Lotus leaf (Nelumbo Nucifera Gaern) is a traditional Chinese medicine with a long history, which is mainly cultivated in southern China
The average recovery of nuciferine in plasma was higher than 90.0%, the intra-day and inter-day coefficients of variation were both lower than 10.0% and the accuracy was higher than 95.0%, which indicated that the recovery of nuciferine in plasma was good, with good precision and accuracy (Table 1), which could fully meet the requirements of this experiment
The results showed that nuciferine was stable in plasma and had significant metabolism in liver microsome (Table 2)
Summary
According to Chinese Pharmacopoeia, Lotus leaf (Nelumbo Nucifera Gaern) is a traditional Chinese medicine with a long history, which is mainly cultivated in southern China. The medicinal lotus leaf can be obtained by cleaning, cutting and drying (2015). Wang et al (2008) studied the pharmacokinetics of nuciferine in beagle dog plasma by reverse high performance liquid chromatography. The results showed that nuciferine distributed rapidly in vivo and eliminated quickly. Liu et al (2010) confirmed that nuciferine was distributed and eliminated rapidly in rat plasma by tail vein injection (Gu et al, 2014). Studies have shown that the pharmacokinetic parameters of nuciferine in rats, such as t1/2β (elimination half-life) and tmax (peak time), are less often affected by the dose, while Cmax (peak concentration of plasma drug) and AUC0-t (area under the concentration-time curve) are directly proportional to the dose. There is no report on the differences of the pharmacokinetic characteristics of nuciferine in different species of animals
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