Abstract
A new method for the oxidation of ergoline alcohols to aldehydes was found (TFFA–DMSO, −78 °C, then DIPEA). Structural features of ergolines required for successful C7–C8 double bond introduction via Polonovski–Potier reaction of respective 6- N-oxides were defined and experimentally confirmed: (i) the presence of electron-withdrawing group at C-8; (ii) trans-diaxial orientation of N6–O and C7–H bonds (both requirements are fulfilled for dihydrolyserg-17-al and its 2,4-dinitrophenyl hydrazone prepared in this work).
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