Abstract
It has been amply demonstrated that hypophyseal extracts containing the growth principle will prevent the gonad-stimulating action of hypophyseal or pregnancy urine extracts in immature or hypophysectomized rats (Smith, Evans, Reiss and Leonard). This inhibitory action was first ascribed by Evans and his coworkers to the growth hormone but later work led them to abandon their original thesis. Investigations along similar lines also indicated that the growth hormone is not the antagonistic principle. Results obtained on the study of this reaction constitute this report.Sexually immature female rats were given 10 R.U. of pregnancy urine extract (Antuitrin S)† subcutaneously, which approximately doubled the weights of the ovaries in 5 days. Litter mates which were concurrently injected with pregnancy urine and extracts of beef and sheep pituitaries containing growth hormone (doses 1 cc. to 5 cc.) prepared after the method of Van Dyke,1 failed to show the increase in weight of the ovaries. The repressing effe...
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