Studies on Nutrition and Tissue Protein

Abstract

In the clinical investigation, preoperative surgical patients were divided into 4 groups by nutrition : (1st group) below 500Cal intake, (2nd group) 500-1000Cal intake, (3rd group) 1000, - 2000Cal intake, (4th group) above 2000Cal intake. After blood and amino acid solution transfusion for them, relationships between their serum protein and tissue protein were observed. The results were as follws : 1) In most cases whose caloric intakes were below 2nd group, ulilization rate of protein was not propotional to their protein intake. In their cases, serum protein and tissue protein could not increase their level by blood and amino acid transfusion. 2) There was narrowly relationship between liver protein and serum protein. Serum protein was kept in normal level by a sacrifice of liver protein in those conditions. In the experimental studies, serum protein, tissue water contents and wound healing was observed in the three groups of gastrectomyzed dogs, 1st proup was supplied with hunger oral feedings, 2nd group was supplied with usual diets and 3rd group was prepared special diets containing high protein and high calorie in early stage after gastrectomy. The results were as follows : 1) In 1st and 2nd group decreased serum and tissue protein but decrement of serum protein was lower than of tissue protein. 2) In 3nd group, incresse of serum and tissue protein was observed, increase rate of serum protein was faster than of tissue protein. 3) Serum protein was kept in normal level by a sacrifice of liver protein. 4) In 3rd group was observed increase of serum and tissue protein, decrease of tissue water contents and increase of wound mechanical strength in comparison with the other groups. These facts were also confirmed by histrogical observations of wounds.