Abstract
Nephrotoxicity following a single and repeated administration of cis-diamminedichloroplatinum (CDDP) was investigated in male Wistar rats. When CDDP in a single dose of 4 mg/kg was injected i.p. into animals, serum creatinine (Cr) and blood urea nitrogen (BUN) reached a peak after 4 days and returned to the initial levels within two weeks. Nephrotoxicity of CDDP was dose-dependent, and related to the route of administration in the following order of i.p.s.c.i.v. When CDDP (4 mg/kg) was injected i.p. repeatedly at intervals of three weeks, a decrease in nephrotoxicity was observed after the 2nd injection of drug. This decreased nephrotoxicity was detected as early as a week after the 1st injection. Following the 3rd injection, nephrotoxicity showed an accumulative pattern. The change in the route of administration or its regimen did not alter the pattern of CDDP-induced nephrotoxicity. Decreased nephrotoxicity after the 2nd injection of the drug seems to be interesting from viewpoint of a host defense response.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
