Studies on Na and K Balance in Bartter's Syndr.

Abstract

This report concerns two children, one male and one female, fifteen and seven years old respectively, diagnosed as Bartter's Syndrome. A sodium and potassium balance was done in each one of these two patients under the next conditions 1) Basal situation;2) overload of ClNH4 at a dose of 200 mEq/m2; 3) spironolaotone at a dose of 3 mgrs/kg/24; 4) Clk at 10 mEq/Kg/24h; 5) Clk at 10 mEq/kg/24h(Case 1)and 7 mEq/Kg/24h (Case 2), plus ClNa at a dose of 4 mEq/Kg/24h; 6) ClK, 7 mEq/Kg/24h, plus ClNa, 4 mEq/Kg/24h plus Mg glueonate, 6 mEq/Kg/24h. During each one of these periods, a daily control of plasma, urinary and intraerithrocyte Na and K concentration was done, as well as on daily food intake and faecal excretion; acidbase balance control was also done. 1. It has been possible to us, to demonstrate the existence of a Na loss syndrome in these two patients. 2.- Under ClK overload, these two patients reached the higher plasma K concentration with positive potassium balance, proving, although incompletely, the negative sodium, balance existing previously. 3.- In our experience, it seems that the positivation of the Na balance benefits the potassium balance, in both patients. 4.- We can't prove clearly the biogenetic effect of Mg on Na and K metabolism; but we can suppose it, at least, in one of these two patients.