Abstract
Di- and triacetyl derivatives of mycobacillin, a cyclic peptide, have been prepared. Acetylation lowers its antifungal activity, the inhibitory concentration (μg/ml) for the diand triacetyl derivatives being 35-40 and 40-45 respectively as against 15-20 for mycobacillin; but acetylation gives complete protection against serum inactivation of the antibiotic whose inhibitory concentration is increased tenfold in its presence.
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