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Abstract
Summary Normal yeast mtDNA contains one cistron each for the rRNA in the 37S and 50S subunits of mitochondrial ribosomes. Genetic information for 50S-rRNA is retained in mtDNA of petites carrying the loci for erythromycin or chloramphenicol resistance. In one strain retaining the erythromycin locus alone, 50S-rRNA hybridized to 14% of the mtDNA, representing a tenfold enrichment of these sequences compared with normal mtDNA. Where oligomycin or mikamycin loci are retained but chloramphenicol and erythromycin loci are deleted, little or no hybridization with 50S-rRNA is observed. Genes for 37S-rRNA are not retained in any of the petites investigated in this work. We conclude that the 50S-rRNA genes are located close to, or encompass, the chloramphenicol and erythromycin loci in mtDNA.
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