Abstract
The physiological disposition and the metabolic fate of hypnotic, 2-methyl-3-o-tolyl-4 (3H)-quinazolinone (MTQ), were studied in man, rat and rabbit. MTQ is rapidly absorbed from the gastrointestinal tract in man and rat. The concentraton of the drug in depot fat is remarkably high compared with that in other tissues in rat. The drug is almost completely metabolized in the body and the rate of biotransformation of the drug is relatively slow. Glucuronides excretion after oral administration of 200 mg./kg. of MTQ was about 20% in a rabbit.
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