Abstract
BackgroundThe metal ion complexes of meropenem and cefixime with cadmium, silver, palladium, zinc, nickel, cobalt and copper were synthesized and characterized by UV, FTIR and H1-NMR spectrophotometry. The antibacterial effects of the complexes were studied using cup and plate method against S. aureus, B. subtilis, E. coli, P. aeruginosa and K. pneumoniae for normal and resistant strains of bacteria. The minimum inhibitory concentration of the metal ion complexes was determined by broth dilution method.ResultsUV spectroscopic studies suggested that meropenem ligand form complex with different metal ions and FTIR spectrum confirmed the proposed structure. Similarly, UV spectrum of cefixime metal ion complexes at λmax 202–295 nm and meropenem metal ion complexes at λmax 249–304 nm was observed in all the complexes. FTIR peaks for a proposed structure were observed in all the meropenem and cefixime metal ion, indicating the formation of complexes, and retained the functional groups of drugs. Meropenem as well as cefixime metal ion complexes exhibited more antibacterial activity against all the selected bacterial strains. Specifically, the lowest minimum inhibitory concentration against P. aeruginosa and K. pneumoniae was observed to be 100 and 150 μg/ml, respectively.ConclusionThe present study concluded that the meropenem and cefixime metal complexes can exhibit the better treatment than individual drug on normal as well as resistant bacteria.
Highlights
The metal ion complexes of meropenem and cefixime with cadmium, silver, palladium, zinc, nickel, cobalt and copper were synthesized and characterized by UV, FTIR and H1-NMR spectrophotometry
The UV absorption spectra of meropenem metal ion complexes showed characteristic peaks from 250 to 295 nm, indicating that there were the presence of n–π* transition and
The results showed that all the synthesized meropenem metal ion complexes possess moderate to good antibacterial activity, where in K
Summary
The metal ion complexes of meropenem and cefixime with cadmium, silver, palladium, zinc, nickel, cobalt and copper were synthesized and characterized by UV, FTIR and H1-NMR spectrophotometry. The role of antibiotic-metal complexes (AMC) in the field of pharmaceutical research has been constantly expanding. It is necessary for the present situation to search for new, more effective and more broadly acting drugs due to an alarming increase in the growing number of drug-resistant bacteria [1]. This growing interest and research activities in the search for new combinations of metal ions with various classes. Metals existing in the nature due to their variable oxidation states, number and types of coordinated ligands and coordinative geometry after complexation can provide variety of properties, whereas the ligands can control the reactivity of the metal, and play
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
