Abstract
A variety of structures, many of which resemble components of liver cells, have been shown to form in clear ultracentrifuged extracts of rat liver. The structures appear after dialysis against isotonic sucrose, pH 7.5 phosphate buffers, or after standing in the cold. When the pH is lowered to 5 or 6, fibrils are readily formed. It is suggested that these structures may form in rat liver breis. The possibility is discussed that cell components exist in equilibrium with their constituent molecules in solution and that mechanisms similar in part to those involved in structure formation in solution may also obtain in the living cell.
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