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Abstract
A convenient two-step synthesis of the title compounds based on the isocyanide chemistry is reported. The Ugi four-component condensation between 4-chloro-2-nitrobenzoie acid (1). aldehydes 2, cyclohexyl isocyanide (3) and α-amino esters as the amino components afforded the expected nitro compounds 5 which were reductively cyclized to the desired 1,4-benzodiazepine-2,5-di-ones 7 via the intermediate amino derivatives 6.
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