Abstract
A system of antibody-mediated cellular immunity against chemically defined haptens has been adopted in order to study the requirements for induction and recall of immunological memory. Hapten-protein conjugates with different molar ratios of hapten to protein were used for immunization. Primed spleen cells were incubated together with 51Cr-labeled CRBC on which the conjugate was coupled by ECDI. Release of radioactivity was assayed. The induction of memory to the hapten was possible regardless of the degree of substitution. Recall of memory, however, was only possible with low substituted conjugates on either homologous or heterologous carriers. The data demonstrate different requirements for induction and recall of memory which possibly are T cell-independent and T cell-dependent processes, respectively.
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