Abstract
Abstract The serum from a patient (GR) with multiple myeloma was shown to contain two unique homogenous bands by cellulose acetate electrophoresis. These components were further identified as a monoclonal IgG2k and a monoclonal IgAk. Rabbit antisera directed against IgG (GR) and IgA (GR) monomer were absorbed to render them specific for individual antigenic (ind) determinants. Both proteins were capable of inhibiting the reaction between labeled protein and its homologous ind antiserum in the radioimmunoassay indicating that both immunoglobulins shared ind determinants. In addition, the determinants shared between the two proteins appear to be identical. The potential sharing of any two heavy chain constant genes among all heavy chain constant genes is discussed.
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