Studies on Hypoglycaemic and Analgesic Activities of Chlorophytum borivilianum Sant and Ferz

Abstract

Objective: To study the anti-hyperglycaemic and analgesic activity of the root extracts of Chlorophytum borivilianum Sant. & Ferz. on rats and mice respectively. Materials and methods: Anti-hyperglycaemic activity of the methanol extract of the roots (100mg & 200mg/kg body weight, p.o.) was evaluated by using both normoglycaemic and alloxan induced hyperglycemic rats of six numbers in a group. The analgesic activity was assessed by using methanol extract of the roots (100mg & 200mg/kg body weight, p.o.) on mice of six numbers in a group by Tail flick and Tail immersion method. Results: The methanol extract was found to produce significant reduction of blood glucose concentration between 2-4 hr. of administration in alloxan induced hyperglycemic rats at tested dose levels. However, in normoglycaemic animals, the extract at 200mg/kg produced significant reduction of blood glucose between 2-4 hr. of administration. In the analgesic study, the root extract showed significant activity. In tail flick method the extract at 100mg/kg showed activity after 45 minutes whereas in tail immersion test, it showed significant activity after 30 minutes interval. Conclusion: Chlorophytum borivilianum Sant. & Ferz. has hypoglycaemic activity and analgesic activity. So it can be recommended for further studies.