Abstract
Hormone secreting adrenocortical tumor cells, previously described in tissue culture, have been further studied. In addition to responding to ACTH, they are stimulated by high concentrations of NADPH and of 3'–5' cyclic AMP, and are able to convert pregnenolone to Δ4-3-keto steroids in the absence of ACTH stimulation. No ascorbic acid was detectable in functioning adrenocortical tumor tissue cultures, and the value was placed at less than 0.5 μg per mg protein or less than 5 per cent of that of the fresh tumor. The adrenocortical tumor cells in culture have a special ability to concentrate ascorbic acid from the medium, and this ascorbic acid can be partially depleted by ACTH stimulation. Steroid 3β-ol dehydrogenase was demonstrated histochemically in tissue cultures of adrenocortical tumor cells.
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