Abstract
Background During the early stage of HIV-1 replication, integrase (IN) plays important roles at several steps, including reverse transcription, viral DNA nuclear import, targeting viral DNA to host chromatin and integration. Previous studies have demonstrated that HIV-1 IN interacts with a cellular lens epithelium-derived growth factor (LEDGF/p75) and that this viral/cellular interaction plays an important role for tethering HIV-1 preintegration complexes (PICs) to transcriptionally active units of host chromatin. Small molecule inhibitors of HIV IN/ LEDGF have emerged as promising new class of antiviral agents for the treatment of HIV/AIDS. Present work is to study the small molecule inhibitor of HIV IN/LEDGF.
Highlights
During the early stage of HIV-1 replication, integrase (IN) plays important roles at several steps, including reverse transcription, viral DNA nuclear import, targeting viral DNA to host chromatin and integration
Previous studies have demonstrated that HIV-1 IN interacts with a cellular lens epithelium-derived growth factor (LEDGF/p75) and that this viral/cellular interaction plays an important role for tethering HIV-1 preintegration complexes (PICs) to transcriptionally active units of host chromatin
Small molecule inhibitors of HIV IN/ LEDGF have emerged as promising new class of antiviral agents for the treatment of HIV/AIDS
Summary
During the early stage of HIV-1 replication, integrase (IN) plays important roles at several steps, including reverse transcription, viral DNA nuclear import, targeting viral DNA to host chromatin and integration. Studies on HIV integrase-LEDGF/p75 interaction inhibitory activity of isatine derivative using the alpha screen luminescent proximity assay From First International Science Symposium on HIV and Infectious Diseases (HIV SCIENCE 2012) Chennai, India.
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