Studies on Hepaplastintest in hepato-blliary diseases

Abstract

Hepaplastintest (HPT) was studied on 96 patients with hepato-biliary discorders at Hirosaki University Hospital and its affiliated hospitals for recent four months.As healthy controls HPT were carried out in 50 males and 50 females of healthy hospital employee. HPT was determined on 3.8% citrated venous blood. Coagulation activity was reported in per cent derived from correlation curve of batch number 163.The mean HPT value±SD for healthy controls was 77±12.0 (male 78.5±13.2, female 75.7±10.7).There was no significant difference in mean value between male and female. The mean HPT value±SD showed 34.7±16.8 in 9 cases with extreme stage of acute hepatitis. In 6 of these 9 cases the author observed precipitous fall of the HPT value to bellow 30%. And severe 4 out of these 6 cases were complicated with disturbed consiousness.The mean HPT values±SD for other various hepatobiliary diseases were as follows: 13 cases on recovery stage of acute hepatitis, 60±16.1; 17 cases with chronic hepatitis, 64.4±13.1; decompensated hepatic cirrhosis, 43.5±8.7; 9 cases with compensated hepatic cirrhosis, 55.3±11.7; 4 cases with primary hepatoma, 55.3±12.0; 11 cases with metastatic tumor of the liver, 65±12.8; and 5 cases with constitutional hyperbilirubinemia including 4 Gilbert diseases, 88±13.1. The mean HPT value for each disease mentioned above, except constitutional hyperbilirubinemia, was significantly lower than that of the control group.HPT was reflected slightly on total protein, S-GOT, S-GPT, fibrinogen, cholesterol and partial thromboplastin time. HPT was correlative apparently with γ-globulin, platelet, prothrombin time with Quick's method (sec), Thrombotest (%) and ICG.Further more HPT was correlative with factor II, VII and X but not with fator IX.If HPT was remarkably impoved in cases with acute hepatitis in spite of the very low initial value less than 30% in the beginning stage of the disease they showed clinical improvement followed by desirable prognosis. It could be suggested the HPT well reflected the synthesis of coagulation factors or the protein synthesis in liver cells.So we could conclude that HPT reflected well the degree of hepatic cellular disfunction and was enable one to suspect the degree in severity and prognosis of the hepatobiliary disorders, especially of acute hepatitis.