Abstract
The present group of studies investigated gold thioglucose as an ulcerogenic agent in guinea pig. Experimental 1 showed that the ulcers produced by this drug reach a peak incidence by the second post-injection day and are no longer present by the fifth day. In Experiment 2, the dose responses of ulcer production by the intracarotid and intrajugular infusions of gold thioglucose were compared. The drug was found to be 5·5 times as potent when given by the carotid route as when given intrajugularly. In Experiment 3, pretreatment with the drug did not significantly influence ulcer formation upon reinjection 50 days later. In Experiment 4, pretreatment with the drug did not influence the development of restraint ulcers 25 days later. The findings of the present studies and compared with other reported studies and discussed in terms of current thoughts concerning the mechanism of gold thioglucose ulcerogenesis and an alternative hypothesis is proposed.
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