Abstract
In the present study, attempts were made to prepare and evaluate the matrix type transdermal patch of Nicorandil, an antianginal and antihypertensive drug using different ratios of polymer concentration of Eudragit RS100, Eudragit RL100, and Ethyl cellulose by the solvent evaporation technique by using 30% w/w of di-butyl phthalate, incorporated as plasticizer. In preformulation studies were determined. The transdermal patches were prepared and evaluated for appearance, weight uniformity, thickness, DSC, XRD, FTIR, Scanning electron microscopy, Water vapor transmission, tensile strength, swelling index, drug content uniformity, in-vitro permeation study through rat skin, skin irritation and stability studies. All the patches were thin, smooth, elastic and transparent/translucent, uniformity in drug content; weight and thickness were observed with their low SD values. The XRD analysis confirmed the amorphous dispersion of the drug. SEM analysis showed surface morphology. The prepared patches were permeable to water vapors. In-vitro drug permeation studies showed formulation UD11 has maximum permeation at the end of 24 hrs. It shown that drug release follows zero order. All the formulations were found to be stable with respect to drug content and physical changes at 400C and 75% RH.
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