Abstract
Human follicle-stimulating hormone (FSH) in urine and serum was determined during various stages of pregnancy by a double-antibody radioimmunoassay method. Out of 241 samples of urine analyzed from 156 women in their third trimester of pregnancy, all except 14 samples showed values that could be measured with reasonable accuracy. The mean ± S.D. values of urinary FSH in pregnancy were found to be 5.04 ± 4.55 U IRP-HMG/24 h. These compare well with FSH values of 5.8 ± 3.1 and 6.11 ± 3.34 U IRP-HMG/24 h found in the follicular and luteal phases, respectively, of the menstrual cycle of non-pregnant healthy women of reproductive age. Serum FSH in pregnancy was found to be very low and out of 223 samples from 103 normal pregnant women only 39 samples showed detectable amounts of FSH. A small positive correlation was found between urinary FSH and total oestrogens but no correlation was found between serum FSH and human chorionic somatomammotrophin (HCS). Implications of these findings are discussed.
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