Abstract
Preliminary studies on fluorescein kinetics in the plasma of humans were performed by fluorophotometry and spectrophotometry. Noninsulin diabetics (type II) were similar to normal individuals. Insulin-dependent diabetics (type I), however, had lower plasma concentrations of fluorescein than the other two groups. No significant differences were found in protein binding among normal volunters and patients with diabetes types I and II. The best time interval for measurement appeared to be 60 min after the intravenous injection. The possible reasons for these results are discussed, and the importance of these findings to vitreous fluorophotometry is outlined.
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