Studies on Fibrinolysis and Coagulation in the Peptic Ulcer (1st Report)

Abstract

(Object) There are many reports on the fibrinolytic dynamics in blood as to the development of peptic ulcers. However, these studies have not been completed and we have many problems to be solved on this subject. In the present study we reexamined the correlation between the fibrinolysis and activity of the coagulation system.(Method) Ulcers were induced by contact freezing of the left gastric artery on the gastric serosa in Mongorel dogs for materials. The basis of ulcers was confined within the limit of the submucosal layer in all cases and fibrin deposit blood vessels were maintained comparatively intact. The plasminogen activator was observed at necrotic portions, but activity was determined at the margin, peripheral elevation and distal mucosa of ulcers and the plasminogen and plasmin inhibitors in the circulating blood were analyzed by affinity chromatography at the same time. The tissue was observed by antifibrinous staining.(Result) At the margin of ulcer: Free plasminogen activator was proved at the local peripheral circulatory insufficiency but it was diministred after this maniplation. In the peripheral elevation of ulcer: Free activator was detected when circulatory insufficiency was invited and a secondary liberation of the activator due to the elevation of membrane permeability of peripheral cells containing quinines was observed. In the distal mucosa: The same correlation as in the peripheral elevation was noticed, but the secondary liberation of activator showed considerably wide variation. The activity of plasminogen or plasmin inhibitors was correlated with that of plasminogen activator in blood. The coagulation system had an inhibitory action on factors V and VIII, but it was correlated with neither PT nor PTT.(Conclusion) The activity of plasminogen activator in the initial lesions of acute peptic ulcers showed clear biphasic peaks and was well correlated with that of plasmin inhibitor or of the coagulation system at the same time.