Abstract
ABSTRACT A study of the capacity of 3 human adrenals and one adrenal adenoma to sulphurylate various steroids and phenol has been undertaken by the use of 35S-labelled 3′-phosphoadenosine-5′-phosphosulphate (PAPS) and inorganic sulphate. The following observations are described. Adrenal extracts are able to accumulate a 35S-labelled compound with electrophoretic properties similar to those of 3′-phosphoadenosine-5′-phosphosulphate (PAPS). Data on sulphokinase and over-all sulphurylating activities are given for the following compounds: androsterone, epiandrosterone, dehydroepiandrosterone (DHA), aetiocholan-3α-ol-17-one, testosterone, pregnan-3α-ol-20-one, pregnan-3β-ol-20-one, pregn-5-en-3β-ol-20-one, 11-deoxycorticosterone (DOC), 17-hydroxy-11-deoxycorticosterone, 11-dehydrocorticosterone, cortisone, corticosterone, cortisol, aldosterone, oestrone, oestriol and phenol. The distribution of the sulphokinases in the adrenal adenoma studied did not deviate significantly from that of the normal glands investigated. The over-all sulphurylating capacity of adult human adrenals with regard to steroids was 33–70 per cent of the corresponding activities of adult human liver, and 14–27 per cent of those of foetal human adrenals. The physiological implications of these results are discussed.
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