Abstract
This study investigated the ET A and ET B receptor subtypes in rat adrenal cortex. The ET A antagonist, BQ-123, inhibited the zona glomerulosa (zg), but not the inner zone (iz) response to ET-1. RES-701-1, the ET B antagonist, abolished the iz response to ET-1, but had less effect on the zg. [ 125I]ET-1 binding studies revealed two receptor subtypes in both zones, with ET A predominating in the zg, and ETB in the iz. These data suggest that the ET A subtype is functionally more important in the zg while the ET B receptor is the major subtype in the inner zones.
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