Studies on Drug Sensitivity and Bacterial Prevalence of UTI in Tribal Population of Paschim Medinipur, West Bengal, India

Abstract

Background: There is paucity of information in regards to prevalence of bacteria in urinary tract infection (UTI) in tribal population. Objectives: This study was conducted to observe dominant organisms causing UTI in tribal community of Medinipur, West Bengal, India and evaluate their sensitivity to common antibiotics. Patients and Methods: A total number of 4,416 urine samples of clinically suspected UTI attending outpatient department and hospitalized tribal patients of West Medinipur zone were collected. Urine samples were inoculated on Blood agar, MacConkey’s agar, and cystine lactose electrolyte deficient (CLED) agar and incubated at 37oC for 24 hr and extended up to 48 hr in cases of negative growth. Antibiotic susceptibility testing against the most common causative bacteria was also performed. Results: A total number of 1,190 samples revealed positive bacterial growth. Seven types of dominant organisms were isolated as causative agents like Escherichia coli (63.44%), Klebsiella sp. (14.62%), Pseudomonas aeruginosa (4.53%), Proteus sp. (4.62%), other Gram negative bacteria (5.79%), Staphylococcus aureus and coagulase negative Streptococci (5.21%), and other Enterococcus sp. (1.76%). E.coli was the most common pathogen of UTI in tribal population with female susceptibility predominantly more than male patients. Among16 antibiotics, amikacin (14.30%) and meropenem (12.0%) were shown to be the most sensitive to and Tobramycin (0.66%) the least effective on E.coli. Conclusions: Females are more susceptible to UTI than males and the most effective drug (sensitive against isolated E. coli) is Amikacin. Therefore, culture and antimicrobial drug sensitivity testing are essential procedures for proper management of UTI in tribal population.