Studies on Density, Viscosity, Partial Molar Volume, Excess Molar Volume, and Excess Viscosity of Panadol in Methanol + Water System At 309.15 K

Abstract

Density and Viscosity of Panadol in various aqueous mixtures of m ethanol-water binary system have been determined at 309.15 K. The density and viscosity data have been analyzed for the evaluation of partial molar volume, molar excess volume, excess viscosity . It can be noticed from these studies that this drug acts as a structure -making compound due to hydrophobic hydration of drug molecules. The values of partial molar volume, Фv and excess molar volume, V E show that as the concentration of Panadol increases the values of Фv decreases and increases with percentage of methanol. The excess molar volume over all concentration range of Panadol is found to be negative. The excess viscosity increases with increase in the molarity of Panadol and over the entire percentage range of methanol in the binary system.