Abstract
Involvement of the adenyl and guanyl cyclase in the process of catecholamine-release evoked by acetylcholine has been studied in bovine adrenal medulla slices. Stimulation of catecholamine-release by acetylcholine was followed by a late increase in cyclic AMP levels at the time when the secretory stimulation was no longer observed. These results suggest that the delayed activation of the medullary adenyl cyclase is not involved in the secretory process but in the restoration or the synthesis of catecholamine after its release. No changes were demonstrated in cyclic GMP levels during incubation.
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