Abstract
The reaction catalyzed by crystalline yeast phosphoglyceric acid mutase is inhibited by the substrate (d-2-phosphoglyceric acid). In order to elucidate the mechanism of this substrate inhibition, detailed investigations have been performed. It is proved that the substrate inhibition in this enzyme reaction is caused by the facts that the coenzyme-binding site on the enzyme is covered by the substrate and the combination of the coenzyme with the enzyme is interfered by the substrate. Consequently, it is concluded that the substrate is a competitive inhibitor of the coenzyme.
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More From: Bulletin of the Agricultural Chemical Society of Japan
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