Studies on Correlation between Renal Biopsy Findings and Renal Function Tests in Several Diseases.

Abstract

1. Kidney biopsy findings in 30 patients with essential hypertension, 20 patients with acuteor chronic nephritis and 2 patients with arteriolosclerosis have been compared with clinical and laboratory findings and the results of discrete renal function tests. As the result, particular attension was given to the correlation between glomerular changes and GFR, minimal blood pressure and presence of red cell in urinary sediment ; between arteriolar changes in the kidney and RPF and retinal findings ; between tubular changes and NPN; between glomerular, tubular and arteriolar changes and NPN, retinal findings and serum-mucoprotein. 2. Kidney biopsy findings in 11 patients with diabetes mellitus have been compared with the clinical and laboratory findings and the results of discrete renal function tests. In 7 cases the biopsy specimen revealed solely diffuse glomerular changes ; in 2 cases nodular-diffuse changes ; and in 1 case hyalinized glomeruli with remnants of nodules ; in 1 case the biopsy showed normal renal tissue. Biopsy of the kidney has some diagnostic value in diabetic nephropathy. 3. Kidney biopsy findings in 3 patients with systemic lupus erythematosus (sLE), 2 patients with diffuse scleroderma and 1 patient with multiple exsudative erythema have been compared with the clinical findings and renal function tests. In 1 case of sLE biopsy specimen revealed wire loop lesion ; in 2 cases glomerular changes. In 2 cases of diffuse scleroderma biopsy findings revealed solely glomerular changes ; in multiple exsudative erythema showed normol renal tissue.