Abstract
1) Acetylation of the thiocyanate compounds (I and II) with acetic anhydride in pyridine afforded the monoacetyl (III) and diacetyl (IV) compounds. 2) Halogenated arylthiocyanate compounds (V to XXVIII) were prepared by dissolving 3-chloro-4-thiocyanatoaniline, 1-amino-4-thiocyanatonaphthalene, 8-amino-6-chloroquinoline, or 8-amino-6-chloro-5-thiocyanatoquinoline in xylene, added with haloacetyl chloride, and heated under reflux for 1 hour. 3) An acid amide compound (XXIX) was prepared by the application of hydrogen peroxide to 5-cyano-1, 6-naphthyridine in acetone. 4) The compounds so synthesized (III to XXIX) were tested for their antibacterial activity in vitvo.
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Schedule a callMore From: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
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