Abstract

Correlation between radioprotection by phenethylamine compounds and anoxia was examined from their action on the blood flow volume of femoral artery in a dog, blood pressure of common carotid artery in a rat, and isolated dorsal artery of a rat. It was found that radioprotection mechanism by vasoconstriction-anoxia was present in the phenethylamine-type and ephedrine-type compounds, while possible participation of anoxia was suggested in some of S-ephedrine-type and isothiourea-type compounds. In disulfide-type and thiosulfate-type compounds, mechanisms other than anoxia were considered to be present.

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