Abstract
The induction of heritable translocations with chemicals in postcopulation germ cells of female mice was investigated. In the methyl methanesulfonate (MMS)-treated group (100mg/kg), 14 partially sterile and 5 sterile males out of 118 F1 male progeny were found. In contrast, in the mitomycin C (MC)- treated group (3mg/kg and 4mg/kg) the frequencies were low. These results indicate that the yield of heritable translocations parallels the formation of chromosome-type aberrations at the first cleavage reported previously.
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