Abstract
The quantitative structure-mutagenicity relationship among 8 substituted styrene oxides, p-methyl-, p-butyl, p-phenyl, p-chloro, m-chloro, p-cyano, p-nitro, and the parent styrene oxide, was examined. Mutagenic and cytocidal activities were correlated with the reactivity of the epoxide (Hammett's σ), the van der Waals volume of the molecule (VW), and/or the partition parameter (π). Multiple regression analyses revealed that mutagenic capacity could be well described by a linear combination of σ and log VW and that cytocidal capacity depended only on π of the derivatives, as already reported by Sugiura et al.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
