Abstract
The synthesis of the orally absorbed 3-ethynylcephalosporin is described. In addition, the structure-activity relationships and oral absorption in rats of 7 beta-[(Z)-2-(2-amino-4-thiazolyl)-2- carboxymethoxyiminoacetamido]cephalosporins having various aliphatic hydrocarbon groups at the 3-position are discussed. Of these cephalosporins, 3-ethynyl-cephalosporin exhibited better activity against Staphylococcus aureus than the other cephalosporins and showed moderate oral absorption in rats.
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