Studies on Atypical Cells Following D & C in Pregnant Women, Abortion and Non-pregnant Women

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Atypical cells following D & C in 153 pregnant women, 34 abortion cases and 30 non-pregnant cases were studied in terms of their origin, appearance rate, time of appearance and cytomorphology. Cytologic specimens were obtained by both cervical scraping and aspiration from the uterine cavity at a proper time after D & C.The cells were sub-classified according to their atypicality and appearance formation. They are cells with mild and severe atypia, and cells isolated and in cluster (sheet and overlapping).(1) The atypical cells presenting severe atypia were found in the specimen from the uterine cavity. The original tissue of these cells were the proliferating endometrium.(2) The atypical cells appeared from the second day, and the number of these cells and atypicality reached the peak on the 7th day. Mild atypical cells were still observed in ca. 70% on the 30th day. In a few cases mild atypical cells were recognized after the first menstrual period since D & C.(3) The cells appeared as isolated form in 25% and in cluster in 75%. It was suspected morphologically that the isolated -cell originated in cluster. The cell detouchirig from the cluster showed the identical cytomorphologic features of the cells in isolated form.(4) The appearance rate and cytomorphologic features of the atypical cells in three different conditions revealed no differences except that the cell size of the pregnant cases were larger than other two conditions.