Abstract
Several bis (2, 3-epoxypropyl) amine derivatives were successfully synthesized by the modification of Homer's method. N, N'-Bis (2, 3-epoxypropyl) piperazine and p-bis (2, 3-epoxypropoxy) benzene were attempted to react with thiols, amines and phenol, and the corresponding ring opening compounds of the epoxide ring were obtained in good yields, respectively. N, N'-Bis (2, 3-epoxypropyl) piperazine and p-bis (2, 3-epoxypropoxy) benzene also reacted with diethyl malonate to give N, N'-bis (γ-ethoxycarbonyl-γ-butyrolacton-α-yl) methyl piperazine and p-bis (γ-ethoxycarbonyl-γ-butyrolacton-α-yl) methoxy benzene, respectively.
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