Studies on Anti-Inflammatory Effect of Ethanolic and Aqueous Extracts of Flowers of Cassia fistula Linn. in Mice and Rat

Abstract

The investigations of Cassia fistula flowers extracts were studied against experimentally anti-inflammatory activity studies and work demonstrates that ethanolic extract and aqueous extract of flowers of Cassia fistula has anti-inflammation activity in mice and rat by carrageenan-induced inflammation and cotton pellet-induced granuloma. From the above observations we can conclude that ethanolic extracts and aqueous extracts flowers of Cassia fistula anti-inflammatory activity at both the dose level which is comparable with the standard. The ethanol extract of Cassia fistula (200mg/kg), markedly increased the percentage of average mean increased in paw volume and weight in cotton pellet by the animals. The anti-inflammatory effect of both the doses (150-200 mg/kg in mice and 200-250 mg/kg in rat) showed significant activity and being that (200 mg/kg) showed higher activity. The inflammatory effects of ethanolic extract and aqueous extract of Cassia Fistula may be attributed to any of or combination of chemicals present in the extract. Further studies are required to identify the active phytoconstituents responsible for the observed inflammatory effect of ethanol extract and aqueous extract. It is suggested and assumed that a further exploration of the present research work is needed to come up with an active anti-inflammatory.